Video above shows how to UEFI-boot using E2B

UEFI-booting using a .imgPTN file

You cannot directly UEFI-boot to the E2B Menu system.
Easy2Boot uses .imgPTN files. A .imgPTN file contains a sector image of a whole partition. This partition must be 'switched-in' and the new partition will replace the E2B partition. The new partition can contain MBR and/or UEFI boot files. E2B can also 'switch-in' two partitions at the same time, so one of the partitions can be an ext4 partition containing an OS or it can be used as a linux swap partition, etc.

For UEFI-bootable partitions, you must first convert an ISO file, .img file or USB drive to a FAT32 .imgPTN file using MakePartImage (download and install the MPI Tool Kit first) - click here for details.

You then copy the .imgPTN file (which is a sector image of a whole partition) to the E2B USB drive. The .imgPTN image file will then be 'switched-in' to completely replace the E2B partition with a new FAT32 partition. You can then UEFI-boot (or MBR-boot) to the new payload files on the new 'switched-in' FAT32 partition.

This is the recommended and most compatible way to boot via UEFI (it also supports Secure Boot if the boot files in your payload are signed as well as MBR\Legacy booting).
It is also possible to have one UEFI-bootable FAT32 partition and an NTFS partition for large >4GB files.
To UEFI-boot from an E2B drive, the process is:
1. First convert the ISO (or other payload) to a FAT32 .imgPTN file using the MPI Tool Kit (drag-and-drop onto Desktop shortcut) and then copy the .imgPTN file to your E2B USB drive.
2. Run \MAKE_THIS_DRIVE_CONTIGUOUS.cmd to make the .imgPTN file contiguous on the USB drive.
3. MBR-boot and select the .imgPTN file from the menu - OR - run \_ISO\SWITCH_E2B.exe and double-click on the .imgPTN file.
    The E2B drive will now contain a completely different partition which will contain your EFI files.
4. Now you can UEFI-boot (or MBR-boot) from the E2B USB drive.
5. When finished, restore the E2B drive partition by MBR-booting to the E2B CSM menu and selecting menu #0 - OR - use \e2b\SWITCH_E2B.exe to restore the E2B partition - OR - use one of the .cmd scripts in the \e2b folder under Windows to restore the E2B partition.
New! 130-page PDF eBook  (complete course on making a multiboot USB drive).
Tip: If you want the 2nd Primary partition on the E2B drive to be kept, use a .imgPTN23 file extension instead of .imgPTN.

Other methods of UEFI-booting

These methods all have disadvantages. You may not be able to boot from all systems, Secure Boot may not work, etc.

1. Use the E2B grub2 menu system (mainly for linux payloads)

You can add a grub2 menu system to E2B (two partitions are required). This is most suitable for USB Hard Disks but can be used with removable USB drives too. The E2B grub2 menu system has the advantage that you may be able to UEFI-boot to some payloads which do not normally support UEFI-booting. You can also directly UEFI-boot from ISO files via grub2 and the ISO files do NOT need to be contiguous.
Secure boot for memtest86 is included - it is also possible to secure boot to some linux payloads (but you will need to use MokManager which will alter the NVRAM of the BIOS in the system that you are booting from).
Because grub2 menus require specific boot parameters, each menu needs to be tailored to each payload and each ISO must use the specific name mentioned in the menu file. The E2B grub2 menu system uses .grub2 menu files which contain the menu entries. You can easily add your own grub2 menu entries by adding more .grub2 files.
Once you have 'switched' to the grub2 menu system however, you may find that some systems will not MBR-boot from the E2B drive until you switch it back to the E2B menu system.

2. Add the UEFI boot files directly onto the E2B drive (not recommended)

If your E2B USB drive is formatted as FAT32 you can add UEFI boot files to the USB drive and then UEFI-boot directly from the E2B USB drive.
WARNING: Adding the UEFI boot add-on may prevent some systems from booting to the E2B menu!
For this reason, I strongly recommend you use separate .imgPTN files for each UEFI payload and do not use this method.
For instance, you could add a dual-boot version of Win8.1SE (WinPE) to the E2B USB drive so that you could boot to WinPE either via MBR booting (if you add a bootmgr .mnu file) or via UEFI booting from either a 32-bit or 64-bit system.
By adding the rEFInd boot manager, you can boot to a variety of different UEFI (.EFI) boot files.
Then, if you UEFI-boot from the E2B drive, you will get a rEFInd GUI icon menu and you can choose to UEFI-boot to Windows, KonBoot or Memtest86.
If you use the rEFInd boot manager, secure booting will not be supported however.
You could add UEFI MemTest86 and UEFI KonBoot files too, as well as add the .mnu files to E2B for normal MBR-boot operation of KonBoot.
The download is available on the Alternate Downloads site and uses rEFInd as a boot manager. Extract the files to a folder on your system and read the rEFInd_READ_ME.txt file for instructions.
Note: It is not possible to add more than one instance of the same OS, unless each one uses a different folder or file structure.