Easy2Boot can support many different filesystems, MBR-payloads, UEFI-payloads, Removable and Fixed Disks, etc.
Use this 'Guide' to help you choose the best way to set up and use an E2B USB drive
1. Type of E2B Drive (Fixed v. Removable USB drive)
When booting Windows-based payloads, it is important to know what type of USB drive you have.
Use RMPrepUSB to check if your USB drive is the Fixed type or Removable type.
E2B is easier to use if the drive is the Removable USB type (e.g. for Windows ISOs), but you can use a USB HDD if you wish (but some changes may be required, see here).
Note that some USB Flash drives can be very slow (even some 'fast' USB 3.0 ones such as Lexar P20!). I highly recommend the SanDisk Cruzer Extreme USB 3.0 Removable USB drive for E2B - but for larger sizes, speed and robustness, a cheap SSD HDD in a fast USB 3.0 non-UASP drive caddy is great!
I also highly recommend the IODD 2531 HDD enclosure - see blog post here.
2. Drive Size
If your USB drive size is less than 137GB, then just use the \MAKE_E2B_USB_DRIVE (run as admin).cmd script. See here.
If your USB drive is larger than 137GB (Flash drive or HDD), then use RMPrepUSB to create a 130GB NTFS partition (do NOT tick the boot as HDD C: option) and then use another tool to create a second Primary partition. See here. This is because many BIOSes have a 137GB limit for USB drives (even recent BIOSes!) - any files placed beyond that point cannot be accessed on some systems (under grub4dos).
Unless you have specific requirements, I recommend you choose NTFS for your E2B USB drive and not FAT32.
You will still be able to UEFI-boot from .imgPTN files if your USB drive is formatted as NTFS.
I do not recommend exFAT for E2B (though it should work) because some Operating Systems cannot access exFAT partitions.
SWITCH_E2B.exe only fully works on NTFS drives.
4. Adding Payloads
Always check the list here for your particular payload and any special instructions.
Always run \MAKE_THIS_DRIVE_CONTIGUOUS.cmd before booting.
If you want to UEFI-boot and MBR-boot, make a FAT32 .imgPTN file using the MPI Tool Kit.
UEFI-booting will only work if the payload supports it and contains the UEFI-boot files.
Booting a file as .ISO may not work correctly if you have a Fixed disk type of E2B USB drive.
.imgPTN files will work on Removable or Fixed disks.
Some payloads do not support UEFI-booting, but if you use the grub2 menu system, it is possible to UEFI-boot to many more linux ISOs.
Below are listed some typical payload files - it is important to know what type of USB drive you have first (Removable or Fixed) because this can affect how they boot...
All types of E2B drive (Removable and Fixed types):
Linux ISOs (MBR booting) - Copy the ISO to any of the standard menu folders (e.g. \_ISO\MAINMENU or \_ISO\LINUX).
Linux ISOs (UEFI-booting) - Copy the .imgPTN file to any of the standard menu folders (e.g. \_ISO\MAINMENU or \_ISO\LINUX).
Puppy Linux ISOs - use the .isopup file extension
Mac puppy - use .isomacpup file extension
Linux + persistence - Find and read the nearest matching .mnu file in the \_ISO\docs\Sample mnu Files\Linux folder.
Windows XP 32-bit Install ISOs (MBR-booting) - Copy to \_ISO\WINDOWS\XP folder
Windows To Go VHD - Copy the .VHD file to any of the standard menu folders (e.g. \_ISO\MAINMENU or \_ISO\WIN).
ERD Commander 2005/2007/MSDaRT5 - use the .isomemF01 or .isomemwinv file extension or use the ERD5_DPMS.mnu sample file.
BartPE - use .isomemF01 or .isomemwinv file extension
Windows Vista+ Install ISOs (MBR-booting + UEFI-booting) - Convert a working bootable USB drive or ISO to a .imgPTN file. Copy the .imgPTN file to any of the standard menu folders (e.g. \_ISO\MAINMENU or \_ISO\WIN) or to the correct \_ISO\WINDOWS\WINxxx folder)
Hiren's/DLC/DLCD/Strelec ISOs (MBR-booting) - Convert the ISO to a FAT32 .imgPTN file.
WinPE ISOs (MBR-booting) - Use file extension of .ISOPE01 or convert to .imgPTN file if that doesn't work